Welcome to WarfarinDosing.org, a free Web site to help doctors
and other clinicians
begin warfarin therapy by estimating the therapeutic dose in patients new to
warfarin. This site is supported by the Barnes-Jewish Hospital at
Washington University Medical Center, the NIH, and donations. Estimates are
based on clinical factors and (when available) genotypes of two genes: cytochrome
P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1).
Recommendations on this Web site are based on
data from over 1000 patients.
Once information is entered onto the next page, the initial estimate of
therapeutic dose explains 53% of the variability in a warfarin dose. If you
return to the Web site and enter an INR value after 3 and/or 4 warfarin doses,
the dose refinement is even more accurate.